{"id":73525,"date":"2024-10-11T16:38:19","date_gmt":"2024-10-11T11:08:19","guid":{"rendered":"https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/?p=73525"},"modified":"2025-08-20T14:28:57","modified_gmt":"2025-08-20T08:58:57","slug":"role-of-genetics-and-brca-genes-breast-cancer","status":"publish","type":"post","link":"https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/2024\/10\/11\/role-of-genetics-and-brca-genes-breast-cancer\/","title":{"rendered":"Is Breast Cancer Hereditary? The Crucial Role Of BRCA In Early Detection"},"content":{"rendered":"<p>Have you ever wondered about the impact of genetics on <a href=\"https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/2022\/10\/15\/what-warning-signs-of-breast-cancer-can-help-detect-it-at-an-early-stage\/\"><strong>breast cancer<\/strong><\/a>? The most common cause of hereditary breast cancer is a mutation in the BRCA1 or BRCA2 gene. <a href=\"https:\/\/protect.checkpoint.com\/v2\/___https:\/\/www.nationalbreastcancer.org\/what-is-brca\/%23:~:text=A%20small%20percentage%20of%20people,mutated%20BRCA1%20or%20BRCA2%20genes.___.YXBzMTphZGl0eWFiaXJsYWNhcGl0YWw6YzpvOmRiZmM5NjliNzRlZDU4MDIwNzE5ZjRhZTUyMDE4OWEzOjY6ZTJmZToyMTk4MGY3ZDBjMmFkMTkzNGI3NjNkZWNiYzc5ODkxZDcxODFjYzcwZGI5ZjU0ODM5NjZhYWE5MmFlYzBlZDJhOnA6VDpO\"><b>About 0.25% of the population<\/b><\/a> carries a mutated BRCA1 or BRCA2 gene.<\/p>\n<h2><strong id=\"The-role-of-genetics-in-breast-cancer\">The role of genetics in breast cancer<\/strong><\/h2>\n<p>Let us explore the role of genetics in breast cancer:<\/p>\n<ul>\n<li>A small percentage of breast cancers are caused by genetic mutations that are passed down through generations. These mutations can occur in genes like BRCA1 and BRCA2. Having one copy of the altered gene in each cell is enough to increase the risk of developing breast cancer.<\/li>\n<li>In addition to BRCA1 and BRCA2, other genes associated with an increased risk of breast cancer include PALB2, ATM, CHEK2, CDH1, STK11, PTEN, TP53, and NF1.<\/li>\n<li>Genetic variation in enzyme activity may be related to breast <a href=\"https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/2022\/02\/09\/what-can-you-do-to-reduce-your-risk-of-cervical-cancer\/\"><strong>cancer risk<\/strong><\/a>.<\/li>\n<li>Genetic factors largely determine the complex estrogen regulation, synthesis, transport, and clearance process.<\/li>\n<li>Other factors that can influence an individual&#8217;s risk of developing breast cancer include reproductive history, contraceptive and hormone replacement use, radiation exposure early in life, alcohol consumption and smoking, and physical inactivity.<\/li>\n<\/ul>\n<h2><strong id=\"What-are-BRCA-genes?\">What are the BRCA genes?<\/strong><\/h2>\n<p>BRCA genes (BReast CAncer genes) are tumor suppressor genes that help repair damaged DNA and prevent cancerous cell changes.<\/p>\n<h3>BRCA1 and BRCA2<\/h3>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-73543 lazyload\" data-src=\"https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/wp-content\/uploads\/2024\/10\/brca-1-1.jpg\" alt=\"brca 1_Activ Living Community\" width=\"800\" height=\"533\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 800px; --smush-placeholder-aspect-ratio: 800\/533;\" \/><\/p>\n<ul>\n<li>BRCA1 helps maintain genomic stability and acts as a tumor suppressor. Mutations in this gene are responsible for about 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. When BRCA1 is functioning properly, it prevents uncontrolled cell proliferation, which is a hallmark of cancer.<\/li>\n<li>BRCA2 is a tumor suppressor gene that helps maintain genome stability. Mutations in this gene are linked to many T-cell lymphomas and chronic lymphocytic leukemias.<\/li>\n<\/ul>\n<p>Everyone has two copies of each BRCA gene, one inherited from each parent. Inheriting a harmful change, or mutation, in one of these genes increases the risk of developing cancers like breast and <a href=\"https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/2019\/09\/16\/understanding-ovarian-cancer\/\"><strong>ovarian cancer<\/strong><\/a>. People with a BRCA mutation tend to develop cancer at younger ages than people without the mutation.<\/p>\n<h2><strong id=\"BRCA-testing\">BRCA testing<\/strong><\/h2>\n<p>BRCA testing is a blood test that looks for changes in the BRCA1 and BRCA2 genes, which can increase the risk of developing certain cancers such as breast, ovarian, prostate, and pancreatic cancers.<\/p>\n<h3>Who should consider BRCA testing?<\/h3>\n<p>You should consider BRCA testing if you have:<\/p>\n<ul>\n<li>A close relative with a known BRCA1 or BRCA2 mutation, or two or more close relatives with breast cancer<\/li>\n<li>A personal history of breast cancer, especially before the age of 50, or with a personal history of ovarian, fallopian tube, or primary peritoneal cancer<\/li>\n<li>Ashkenazi Jewish ancestry, or Eastern European Jewish ancestry, and a moderate family history of breast and ovarian cancers<\/li>\n<\/ul>\n<h3>Understanding the test results<\/h3>\n<p>Testing for inherited changes in BRCA genes in breast cancer can give the following results:<\/p>\n<ul>\n<li>A positive test result indicates that a person has a harmful change in BRCA1 or BRCA2 and has an increased risk of developing certain cancers. However, a positive test result cannot tell whether or when the tested individual will develop cancer.<\/li>\n<li>A negative result can have several meanings. If a close blood relative of the tested person is known to carry a harmful change in BRCA1 or BRCA2 and the laboratory was aware of that variant when performing the testing, it means the tested person did not inherit the harmful change that is present in the family and cannot pass it to their children. However, if the tested person has no personal history of cancer or their family isn\u2019t known to carry a harmful variant, then the negative result does not provide additional information about their risk of cancer beyond what is known about their family history and other risk factors they may have.<\/li>\n<li>A \u201cvariant of uncertain significance,\u201d or VUS result implies a change in BRCA1 or BRCA2 for which there is not enough data available to conclude that it increases cancer risk.<\/li>\n<\/ul>\n<h2><strong id=\"Prevention-and-early-detection\">Prevention and early detection<\/strong><\/h2>\n<p>If you have inherited a harmful change in BRCA1 or BRCA2, you have several options for reducing cancer risk. These include enhanced screening, risk-reducing surgery, and taking medication to reduce the risk.<\/p>\n<h3>Regular checkups and screenings<\/h3>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-73539 lazyload\" data-src=\"https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/wp-content\/uploads\/2024\/10\/brca-2.jpg\" alt=\"brca 2_Activ Living Community\" width=\"800\" height=\"533\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 800px; --smush-placeholder-aspect-ratio: 800\/533;\" \/><\/p>\n<p>Women who have inherited harmful changes in BRCA1 and BRCA2 should start breast <a href=\"https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/2024\/02\/02\/cancer-screening\/\"><strong>cancer screening<\/strong><\/a> at younger ages and have screening with magnetic resonance imaging (MRI) in addition to mammography. Men with harmful inherited changes in a BRCA gene should discuss screening options with their healthcare provider.<\/p>\n<h3>Lifestyle modifications<\/h3>\n<p>Some lifestyle modifications that can help reduce the risk of breast cancer include:<\/p>\n<ul>\n<li>Maintaining a healthy weight throughout life and regular physical activity, such as walking or jogging.<\/li>\n<li>Avoiding alcohol and smoking.<\/li>\n<li>Eating a <a href=\"https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/2021\/11\/12\/how-to-maintain-a-healthy-and-balanced-diet-for-diabetics\/\"><strong>balanced diet<\/strong><\/a> full of fresh fruits and vegetables.<\/li>\n<li>Breastfeeding, if possible.<\/li>\n<li>Avoiding certain birth control pills.<\/li>\n<li>Avoiding hormone therapy for menopause.<\/li>\n<li>Getting regular breast screenings.<\/li>\n<li>Managing stress.<\/li>\n<\/ul>\n<h3>Risk-reducing surgery options<\/h3>\n<p><a href=\"https:\/\/protect.checkpoint.com\/v2\/___https:\/\/www.cancer.gov\/types\/breast\/risk-reducing-surgery-fact-sheet___.YXBzMTphZGl0eWFiaXJsYWNhcGl0YWw6YzpvOmRiZmM5NjliNzRlZDU4MDIwNzE5ZjRhZTUyMDE4OWEzOjY6MDI4NTowNjJjZGJiODllYzFiYjEwOGFiNzFmOWMxNDA2YTY1NDg4MGRkZTI1NjExMmNmYWEzMjhiOWE3MWY1YjlhZWRkOnA6VDpO\"><b>Risk-reducing surgery<\/b><\/a> involves removing as much of the tissue where cancer may develop as possible. Women may choose to have both breasts removed (bilateral risk-reducing mastectomy) to reduce their risk of breast cancer. Surgery to remove the ovaries and fallopian tubes (bilateral risk-reducing salpingo-oophorectomy) can help reduce the risk of ovarian cancer and, possibly, breast cancer.<\/p>\n<p>BRCA genes might impact the development of breast cancer. While any type of cancer might seem daunting, prevention and early detection are keys to supporting long-term management and health. Incorporate healthy lifestyle changes to keep cancer at bay and ensure long-term well-being.<\/p>\n<div class=\"key-takeaway__content-wrap\">\n<h3><\/h3>\n<h3 class=\"key-takeaway__sub-heading\">Key Takeaways<\/h3>\n<div class=\"key-takeaway__content\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\">A small percentage of breast cancers are caused by genetic mutations that are passed down through generations. These mutations often occur in the BRCA1 and BRCA2 genes.<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">BRCA genes are tumor suppressor genes that play a crucial role in repairing damaged DNA and preventing the development of cancerous cells.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">BRCA testing is a blood test that screens for mutations in the BRCA1 and BRCA2 genes. These mutations can significantly increase the risk of developing certain cancers, including breast, ovarian, prostate, and pancreatic cancers.<\/span><\/li>\n<li aria-level=\"1\">To reduce this risk, several options are available, including enhanced screening, risk-reducing surgery, and medication.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Stay tuned to the Activ Living Community. Keep up to date with the latest health tips and trends through expert videos, podcasts, articles, and much more on<\/span><a href=\"https:\/\/protect.checkpoint.com\/v2\/___https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/category\/diet-and-nutrition\/___.YXBzMTphZGl0eWFiaXJsYWNhcGl0YWw6YzpvOjk5OGQ2YmY0YzA2ODgwNDA2ZGRlOGY5NjQxNzUxMzQwOjY6NWZmOToyZDE5NWY3ZDZkOGE4ZGRiMzMwYTk0YjkxZWE0MTIwYTQ2ZDZmZWQzNGQ5OGEwMGYzY2FjOWUzNmZhYTA5OTkyOnA6VDpO\"> <b>nutrition<\/b><\/a><b>,<\/b><a href=\"https:\/\/protect.checkpoint.com\/v2\/___https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/category\/health-and-fitness\/___.YXBzMTphZGl0eWFiaXJsYWNhcGl0YWw6YzpvOjk5OGQ2YmY0YzA2ODgwNDA2ZGRlOGY5NjQxNzUxMzQwOjY6OWE3ZTowODU0MGJjMGMyNzk5MDNkMjI1ZTEzOGY1YTczM2NiMDEzYTcwZGI1ZGVmY2E1ZDQwMWIzZGM0NDQ2MDRiY2Q3OnA6VDpO\"> <b>fitness<\/b><\/a><b>,<\/b><a href=\"https:\/\/protect.checkpoint.com\/v2\/___https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/category\/mindfulness\/___.YXBzMTphZGl0eWFiaXJsYWNhcGl0YWw6YzpvOjk5OGQ2YmY0YzA2ODgwNDA2ZGRlOGY5NjQxNzUxMzQwOjY6YjI2NDo1ODYwNTgzODRmYzk0YzQ0MjkzNDhmOTE0NTYxNzVjYThlZmQwNTQzZGJjYzFmOGY2YmNhNDU2ODAwZmI1ZTI0OnA6VDpO\"> <b>mindfulness<\/b><\/a><b>, and<\/b><a href=\"https:\/\/protect.checkpoint.com\/v2\/___https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/category\/lifestyle-conditions\/___.YXBzMTphZGl0eWFiaXJsYWNhcGl0YWw6YzpvOjk5OGQ2YmY0YzA2ODgwNDA2ZGRlOGY5NjQxNzUxMzQwOjY6ZTU5Mzo3MGM1N2M5Y2Q1NTJlODQ0ZjFlNDZjMGQyYTk1MDk0ZTM2M2ZkNjc3ZjUzMzUwNzRjMmFkNjRjOGE1OWVkM2IxOnA6VDpO\"> <b>lifestyle conditions<\/b><\/a><span style=\"font-weight: 400;\"> like Asthma, Blood Pressure, Cholesterol, and Diabetes. 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href=\"https:\/\/protect.checkpoint.com\/v2\/___https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/health-tools\/blood-pressure\/___.YXBzMTphZGl0eWFiaXJsYWNhcGl0YWw6YzpvOjk5OGQ2YmY0YzA2ODgwNDA2ZGRlOGY5NjQxNzUxMzQwOjY6M2E4Yjo5OGQxZTg0NDg2M2IwOWNjOTc1ZjM4Zjk2MDExNmIxOGE2YTdiZThhN2Q3Njc1YTUzNzZmOGYyMTc5ZWMwNWM3OnA6VDpO\"><span style=\"font-weight: 400;\"> Blood pressure calculator<\/span><\/a><span style=\"font-weight: 400;\"> |<\/span><a href=\"https:\/\/protect.checkpoint.com\/v2\/___https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/health-tools\/blood-glucose\/___.YXBzMTphZGl0eWFiaXJsYWNhcGl0YWw6YzpvOjk5OGQ2YmY0YzA2ODgwNDA2ZGRlOGY5NjQxNzUxMzQwOjY6NjIyYzplMjkxNTU3NjJkMTRkNjU5M2NmYmE5ZTQzNGRjNDk2YWRmMzY4YjFmNjFmYzViZDVjZmZmY2I0ZDU1NDJkZjlkOnA6VDpO\"><span style=\"font-weight: 400;\"> Blood sugar calculator<\/span><\/a><span style=\"font-weight: 400;\"> |<\/span><a href=\"https:\/\/protect.checkpoint.com\/v2\/___https:\/\/www.adityabirlacapital.com\/healthinsurance\/active-together\/health-tools\/bmi-calculator\/___.YXBzMTphZGl0eWFiaXJsYWNhcGl0YWw6YzpvOjk5OGQ2YmY0YzA2ODgwNDA2ZGRlOGY5NjQxNzUxMzQwOjY6NzUwMzpkM2QxNThiZDNmNTExODU5ODJmMzg1NGZhOTY4N2VmZDdiMDNiMGQyOGZhZGU3MjI3MWNjMTYyMjYwZmVmMjBhOnA6VDpO\"><span style=\"font-weight: 400;\"> BMI Calculator<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Have you ever wondered about the impact of genetics on breast cancer? The most common&#8230;<\/p>\n","protected":false},"author":2963,"featured_media":73540,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4237,8],"tags":[4417,4416],"class_list":["post-73525","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer-lifestyle-conditions","category-lifestyle-conditions","tag-brca-genes-in-breast-cancer","tag-genetics-in-breast-cancer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Is Breast Cancer Hereditary? The Crucial Role Of BRCA In Early Detection<\/title>\n<meta name=\"description\" content=\"The role of genetics in breast cancer is undeniable. 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